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鼠抗人CD61單克隆抗體產(chǎn)品更新

單克隆抗體是由單一B細(xì)胞克隆產(chǎn)生的高度均一、僅針對(duì)某一特定抗原表位的抗體。通常采用雜交瘤技術(shù)來(lái)制備，雜交瘤（hybridoma）抗體技術(shù)是在細(xì)胞融合技術(shù)的基礎(chǔ)上，將具有分泌特異性抗體能力的致敏B細(xì)胞和具有無(wú)限繁殖能力的骨髓瘤細(xì)胞融合為B細(xì)胞雜交瘤。

CD61是一種110 kDa膜糖蛋白，也稱(chēng)為整合素β3鏈或GPIIIa。CD61可與整合素αV鏈（CD51）或整合素βIIb鏈（CD41，GPIIb）結(jié)合，形成細(xì)胞戰(zhàn)術(shù)素、纖維連接蛋白、纖維蛋白原、層粘連蛋白、基質(zhì)金屬蛋白酶-2、骨橋蛋白、骨調(diào)節(jié)蛋白、纖溶酶原、血小板反應(yīng)蛋白、玻璃體凝集素和血管性血友病因子的異二聚體受體，一些成纖維細(xì)胞、一些活化的白細(xì)胞和腫瘤細(xì)胞。GPllb llla（CD41-CD61）在血小板和巨核細(xì)胞潛能細(xì)胞中的分布受到限制，是血小板聚集所必需的。

Catalog Number:  XF-22153A

Size: 100ug:  100ug 1mg/ml

Source:  Mouse
Purification method:  Purified by protein-A affinity chromatography

Isotype:  Mouse IgG1 kappa

Storage:  PBS with 0.1% sodium azide.Store at 2-8°C.

Immunogen:  N/A

Full name:  integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Calculated molecular weight:  788 aa, 87 kDa

Gene symbol:  ITGB3

Synonyms:  CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3

Species Specificity:  Human, Non-human primates；other species not tested

Positive FC detected in:  Human peripheral blood platelets

Recommended dilution:  This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.